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GLP-1 Receptor Agonists – From Evolution to Revolution

Besides being more convenient for the patient, there seem to be added benefits of creating a more stable pharmacodynamics profile (i.e., reducing the peaks and troughs of drug action) as these drugs induce less nausea, a common side-effect of rapid-acting compounds (19, 50, 98, 194)

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Suggesting that variable β-arrestin recruitment of our agonists may indeed influence their capacity for pharmacological insulin secretion, insulin release from dual β-arrestin knockdown was consistently increased