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However, GLP-1 was found to be proteolytically degraded and inactivated by the ubiquitous protease dipeptidyl peptidase-4 (DPP-4) [8] and both the intact GLP-1 molecule and DPP-4-generated metabolites (GLP-1 [9–36 amide] or [9–36]) were subject to rapid elimination from the circulation, with an elimination half-life of approximately 2 min [9]
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After waiting at least 30 minutes following Rybelsus administration, patients may eat and take other oral medicines
