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Crucially, despite this variability, subsequent meta-analyses pooling the data from injectable GLP-1RAs have demonstrated a significant overall reduction in the risk of hospitalisation for HF with GLP-1RAs.36 Dedicated Heart Failure Trials The STEP-HFpEF, STEP-HFpEF DM and SUMMIT trials represent key advances in the evaluation of GLP-1RAs in the treatment of HF

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One cause of the increased risk of myocardial infarction in diabetes is the development of resistance to GLP-1