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Lateral hypothalamic GLP-1 receptors are critical for the control of food reinforcement, ingestive behavior and body weight
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It is well known that HFD-induced obesity promotes low-grade hypothalamic inflammation, causing deregulation of central mechanisms that control energy homeostasis 59 , and both physical exercise and some pharmacotherapies have been shown to improve systemic metabolism by attenuating hypothalamic inflammation 60,61
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