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What Causes a False-Positive Pregnancy Test?

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Pharmacological studies with truncated, chimeric, and mutated ligand and receptor variants, together with peptide ligand-bound ECD crystal structures and the first 7TM crystal structures of class B GPCRs, have provided the basis for a two-domain–binding mechanism of peptide hormone ligands to secretin-like class B GPCRs (Parthier et al., 2009