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Percentage Change in Body Weight The mean on-treatment change in body weight was −5.9% (95% CI, −6.0% to −5.8%) for tirzepatide vs −3.6% (95% CI, −3.7% to −3.4%) for semaglutide at 3 months, −10.1% (95% CI, −10.4% to −9.9%) vs −5.8% (95% CI, −6.0% to −5.5%) at 6 months, and −15.3% (95% CI, −16.0% to −14.5%) vs −8.3% (95% CI, −9% to −7.6%) at 12 months (Figure 4)
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