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Housing mice near vs. below thermoneutrality affects drug-induced weight loss but does not improve prediction of efficacy in humans: Cell Reports

INSL5 administration increased food intake in wildtype mice but not in mice lacking its receptor RXFP4, contrasting with the anorexic properties of other L-cell hormones [Grosse et al

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Your metabolism may also have a short adjustment window as your receptor profile shifts from GLP-1 alone to GLP-1 plus GIP