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For example, in a double transgenic mouse model of AD (APP/PS1), brain levels of pro-inflammatory cytokines (IFNฮณ, IL-1ฮฒ, and IL-4), reactive astrocytes, and IRS-1 phosphorylated at serine 616 (a marker of IR (99, 178)) were raised, suggesting that neuroinflammation and IR interact in the AD brain (167)