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Furthermore, in vitro studies revealed that exendin-4 alleviated neuronal damage induced by high glucose and oxidative stress, and in the icv-STZ-induced rat model, it improved learning and memory by downregulating GSK-3β activity, thereby reversing tau hyperphosphorylation and safeguarding hippocampal neurons from degeneration [102]
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When patients were initiated into subcutaneous semaglutide and later switched to orforglipron, weight loss remained stable but new adverse effects appeared
