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46 Thyroid hormone receptor β agonist: resmetirom (MGL-3196) Thyroid hormone receptor β agonist, highly expressed in hepatocytes, regulates many metabolic pathways, including the reduction of triglyceride and cholesterol levels, improvement of insulin sensitivity, promotion of liver regeneration, and reduction of cell apoptosis

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Muscle loss has emerged as a concern in some studies, with 25–35% of weight reduction potentially coming from lean mass depending on exercise and protein intake