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In contrast, human GIPR mRNA was exclusively detectable in GIPR/GLP1R double humanized mice (B-hGIPR/hGLP1R, H/H) but not in wild-type controls

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Safety data from STEP UP demonstrated the tolerable profile of semaglutide 7.2 mg, with most signals mild-to-moderate gastrointestinal events, consistent with the glucagon-like peptide-1 receptor agonist (GLP-1 RA) class