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Patients who started a GLP-1 were approximately 43% less likely to progress to Stage IV disease than patients who started a DPP-4 inhibitor, with a hazard ratio of 0.57 (95% confidence interval 0.46 to 0.71)
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GLP-1 increases insulin secretion when blood sugar is high, suppresses glucagon secretion, slows gastric emptying, and signals satiety to the brain
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