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Potential clinical investigations may include: Comprehensive metabolic panel and hemoglobin A1c to assess diabetes control Hormone levels when clinically indicated (such as morning testosterone in men with symptoms of hypogonadism) Cardiovascular assessment, as erectile dysfunction can be an early marker of cardiovascular disease [27] [28] Screening for depression and anxiety, which frequently affect libido Pregnancy testing when appropriate Never discontinue semaglutide or adjust dosing without medical guidance