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Pharmacokinetics: metabolized through the hepatic cytochrome P450 system Side Effects / FDA Warning: The FDA issued a black box warning to indicating an increased risk of heart failure with both pioglitazone & rosiglitazone Long term therapy is associated with a small increase in HDL & LDL & a decrease in Triglycerides The triglyceride lowering effect of pioglitazone is greater than that of rosiglitazone, presumably due to its stimulatory effects on PPAR-α (which may be due to decreased osteoblast formation)
'-Primary Health Interest: Beauty
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Incretins are hormones released from the gastrointestinal tract into systemic circulation and are involved in glycemic regulation
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