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Notably, this same study confirmed the abundance of the GLP-1R on brain vascular endothelial cells (93, 94) that has been reported to potentially mediate arteriolar dilation and, thereby, regulate tissue perfusion (95)

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This subset of diagnoses is not only large (and growing) but affects a disproportionately large portion of the overall population, and accounts for an even larger portion of morbidity and overall mortality