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Yes, GLP-1 medications (semaglutide and tirzepatide) have been proven safe for long-term use in clinical trials lasting up to 2+ years
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Moreover, for people already dealing with substance abuse, it decreased adverse events and the risk of death by 50%.[ref] Phamacogenomics and GLP-1 RAs: There’s an individual variability in treatment response to most medications, including GLP-1 RAs
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