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Use of GLP-1 Ras, in people with obesity (PwO) may also have skeletal impacts in part because obesity may itself predispose to altered micro-architecture and greater fracture risk

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While semaglutide demonstrated a favorable safety and tolerability profile and was associated with modest changes in AD-related biomarkers, including plasma high-sensitivity C-reactive protein and AD-relevant cerebrospinal fluid biomarkers, it did not demonstrate superiority over placebo on the primary clinical endpoint, change in the clinical dementia rating–sum of boxes (CDR-SB) score at week 104 68