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While the known adverse effects of pharmaceutical-grade semaglutide are well-documented—including nausea, vomiting, diarrhea, constipation, and abdominal pain—the risk profile of compounded versions may differ due to formulation variables, impurities, or inconsistent potency

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The interaction between GLP-1R and alcohol was further found in a nationwide cohort study investigating the risk of alcohol-related events in patients with a prescription of GLP-1-based therapies (37)