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Compared with untreated individuals, those receiving GLP-1 therapy showed lower levels of pro-inflammatory cytokines (IL-6, TNF-α, IL-12), higher levels of IL-10, reduced expression of endothelial adhesion molecules (ICAM-1, VCAM-1), and decreased leukocyte rolling and adhesion along the vascular endothelium [15]
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Gastrointestinal side effects, particularly diarrhea, occur in approximately one in five patients starting semaglutide therapy
