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Semaglutide hits one receptor. Tirzepatide hits two. Retatrutide hits three. The third receptor is the glucagon receptor — GCGR. And adding it changes the metabolic equation entirely. Glucagon is the counter-regulatory hormone
A randomised, active- and placebo- controlled, three-period crossover trial to investigate short-term effects of the dipeptidyl peptidase-4 inhibitor linagliptin on macro- and microvascular endothelial function in type 2 diabetes
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