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Por otro lado, los GLP1-RA pueden usarse en pacientes con enfermedad renal crónica moderada a severa, donde los inhibidores del SGLT-2 pierden su eficacia y no son recomendados 144
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Smith et al (102) demonstrated that the effect of CCK was likely not due to CCK crossing the blood-brain barrier but rather was mediated by CCK activation of abdominal vagal afferent fibers that stimulate neurons in the brain (103)
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