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The novel biguanide MC001 showed much stronger antitumor effect and relatively weaker proglycolytic activity compared with metformin as shown in vitro in colorectal cancer cells ( in vitro by modulating the AMPK-mTOR and androgen receptor signaling pathways ( In vivo , NT1014 reduced tumor weight by 61%, whereas metformin by only 32%
Target-Women
Size:7mg
All 4 RCTs were multicentered (mean number of clinical sites 50) and multinational (most were done in US and Europe)
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