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Clinical research on the FDA-approved branded versions of these active ingredients includes the STEP-1 trial, which demonstrated mean weight reduction of approximately 14.9% with semaglutide over 68 weeks, and the SURMOUNT-1 trial, which showed tirzepatide achieving 16–22.5% weight reduction over 72 weeks

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Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits

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