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Additionally, HM15136, a novel glucagon mono-agonist with an IgG4 Fc fragment conjugated to the C-terminal end, exhibits an enhanced 36 hr half-life, high GcgR specificity, high solution stability, and potent hyperglycemic properties

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Slower Adjustment to Appetite and Digestive Changes Some patients describe a preference for gradual changes rather than rapid shifts in hunger or digestion