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GLP-1 Therapies and Risk of Muscle Loss Glucagon-like peptide-1 (GLP-1) medications have increasingly been prescribed to treat cardiometabolic conditions such as obesity, diabetes, and cardiovascular diseases—Yeo et al (2024) conducted a nationwide analysis on the usage of GLP-1's in patients without diabetes and observed a 700% (from 21,000 in 2019 to 174,000 in 2023) increase between the years 2019-2023