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Nested basket cohorts within the same registrational program measured knee osteoarthritis pain on the WOMAC scale and obstructive sleep apnea severity on the apnea-hypopnea index, with Lilly reporting up to 73.1 percent pain-score improvements and up to 60.6 percent AHI reductions at 80 weeks in topline ADA releases

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Heart rate effects should be evaluated in the context of overall tolerability and treatment goals