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There are a number of reasons for the frequent use of this therapy: from a pathophysiological point, the metformin/DPP-4 combination leads to higher GLP-1 concentrations compared to a therapy with a DPP-4 inhibitor alone (75)
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It also helps with gastric emptying, slowing the time it takes for the stomach to empty, and interacts with areas in the brain that signal satiety
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